B cells mature

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B cells, also known as b lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system by secreting antibodies. Additionally, b cells present antigens (they are also classified as professional antigen-presenting cells (apcs)) and secrete cytokines. In mammals, b cells mature in the bone marrow, which is at the core of most bones. In birds, b cells mature in the bursa of fabricius, a lymphoid organ where they were first discovered by chang and glick, (b for bursa) and not from bone marrow as commonly believed. In mammals, b cells mature in the bone marrow, which is at the core of most bones. In birds, b cells mature in the bursa of fabricius, a lymphoid organ where they were first discovered by chang and glick, (b for bursa) and not from bone marrow as commonly believed. Early b cell development and commitment to the b cell lineage occurs in the foetal liver prenatally, before continuing in the bone marrow throughout life. B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin (ig) directed against invasive pathogens (typically known as antibodies). Although mature lymphocytes all look pretty much alike, they are extraordinarily diverse in their functions. The most abundant lymphocytes are b lymphocytes (often simply called b cells) and t lymphocytes (likewise called t cells). -found only in t and b lymphocytes and are only active in immature lymphoctytes which is why bcr and tcr rearrangements do not continue in mature t and b cells rag proteins -cleave dna at recombination sequences which are located adjacent to the v, d or j coding sequence.

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