E) cannot make new proteins and will be worn out within a few months. Red blood cells gradually become filled with hemoglobin, their nuclei and other organelles are forced out. Cannot make new proteins and will be worn out within a few months. Get an answer to your question after losing its nucleus, what ability does a mature red blood cell lack. In biology if there is no answer or all answers are wrong, use a search bar and try to find the answer among similar questions. Mature red blood cells lack nuclei and mitochondria-cannot synthesize or divide. It may affect a persons health and red blood cell count can diagnose and evaluate the courses of any diseases. A mature red blood cell cannot reproduce because it lacks a (blank) that was extracted during late development. Then the mature red blood cell becomes a useless cell without any knowledge on how to do its job. It will then float through your blood stream until it is absorbed. A mature red blood cell doesnt have a nucleus while an immature one does.